Description

In his new book, Patrick Holford explains why Alzheimer’s is a preventable disease. Less than 1% of cases are caused by genes. We already know how to prevent at least 8 out of 10 cases and cut your risk by at least 80% if not completely for the vast majority of people. Later in life you may lose your hair but you never need to lose your memories. This book explains how.

• Learn  the truth about amyloid and p-tau, the targets for ineffective drugs.
• Discover which genes do cause Alzheimer’s, which predict increased risk and how to eliminate that risk.
• Understand why Alzheimer’s will not be solved by a drug since it is not caused by one thing but a combination of factors, different for each person, that create the ‘perfect storm’ that leads to brain degeneration and cognitive decline.
• Explore how to assess your weakest links that drive future risk
• Unlock exactly how to dementia-proof your diet and lifestyle

“It is clear that Patrick Holford has seen through the dogma around drug development for Alzheimer disease and that the emperor has no clothes. More importantly, Alzheimer prevention is both scientifically plausible and, indeed, actually works in practice.”

Professor Stephen Cunnane, Université de Sherbrooke, Canada

Published 1 May, 2025.

Praise for Alzheimer’s: Prevention is the Cure

“Becoming an Alzheimer’s patient is almost always a choice. This book explains why.” Dr David Perlmutter, neurologist

“Superbly researched book. “Patrick Holford has been a leader in the field of dementia prevention for years.” Dr Dale Bredesen, author of The End of Alzheimer’s

“This book succinctly and fearlessly promotes prevention as the way forward in the battle against Alzheimer’s disease.” Professor Joshua Miller, Rutgers University

“The book must lead to a change in official policies!” Professor David Smith, University of Oxford

“A beacon of hope for the future of brain health.” Dr Atsuo Janigisawa, Japan

“We must popularise prevention. This is the way forward.” Gao Qiang, former Minister of Health, China.

“A must-read for anyone looking to safeguard their mind.” Dr Sabine Donnai, VIAVI CEO.

“This book is an excellent primer on how to reduce your own risk of developing dementia.:” Dr Andrew McCaddon, retired GP

“Hugely well-informed and hopeful handbook.” Jerome Burne, award-winning medical journalist

Introduction

PART 1 – WHAT DOES & DOESN’T CAUSE ALZHEIMER’S

1. Amyloid ≠ Alzheimer’s and the Tauist’s Delusion
2. Less than 1% is ‘in the Genes’ and the ApoE4 exaggeration
3. Alzheimer’s is Caused by a Systems Breakdown

PART 2 – THE 8 PREVENTION DOMAINS

4. The Four Biological Horsemen of the Brain Apocalypse
5. Brain Fats – Omega-3, Phospholipids, Vitamin D and Cholesterol
6. Methylation, Homocysteine and the Causal Role of B vitamins
7. Omega-3 and B vitamins – the Dynamic Duo
8. How our Sugared Brains are ‘Fructed’ and How Ketones aid Recovery
9. Anti-age your brain with antioxidants, glutathione and NAC
10. Use it or Lose it – Lifestyle Factors that Protect Your Brain
11. Brain Recovery and Repair – the Sleep, Stress and Hormone Connection
12. Microbes and the Mind

PART 3 – PREVENTION IN ACTION Your Alzheimer’s Prevention Plan

13. Assessing and Reversing Your Risk with the Cognitive Function Test
14. Your Alzheimer’s Prevention Plan – Diet, Supplements & Lifestyle
15. The Global Citizen Science Alzheimer’s Prevention Revolution

Recommended Reading

Resources

Index